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Apatite coating on anionic and native collagen films by an alternate soaking process

Paper ID Volume ID Publish Year Pages File Format Full-Text
2210 103 2007 6 PDF Available
Title
Apatite coating on anionic and native collagen films by an alternate soaking process
Abstract

The present study focuses on apatite coating on collagen films, with various different densities of carboxyl groups, using an alternate soaking process. Anionic collagen (AC), which has different densities of carboxylic groups compared to native collagen (NC), was obtained by hydrolysis of carboxyamides of asparagine and glutamine residues. From X-ray diffraction analysis, apatite was found to be coated on AC and NC films. Peaks ascribed to apatite were observed at 26° and 32° in the diffraction patterns of hydroxyapatite crystals. The amount of apatite coated on both AC and NC collagen films continued to increase up to 100 reaction cycles. However, there is a significant difference in apatite coating between the two films. The amount of apatite formed on the surface of AC film increased 1.24 times faster than on NC film. The scanning electron photomicrograph images of the mineralized NC and the AC film coatings formed after 100 cycles show that regular porous apatite coating had formed within the collagen fibrils. These results suggest that the higher content of carboxyl groups in AC plays an effective role in the heterogeneous nucleation of apatite in the body environment.

Keywords
Apatite coating; Anionic collagen film; Alternate soaking process
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Apatite coating on anionic and native collagen films by an alternate soaking process
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 3, Issue 5, September 2007, Pages 773–778
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering