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Conversion of sea urchin spines to Mg-substituted tricalcium phosphate for bone implants

Paper ID Volume ID Publish Year Pages File Format Full-Text
2212 103 2007 9 PDF Available
Title
Conversion of sea urchin spines to Mg-substituted tricalcium phosphate for bone implants
Abstract

The skeleton of sea urchin spines is composed of large single crystals of Mg-rich calcite, which have smooth, continuously curved surfaces and form a three-dimensional fenestrated mineral network. Spines of the echinoids Heterocentrotus trigonarius and Heterocentrotus mammillatus were converted by the hydrothermal reaction at 180 °C to bioresorbable Mg-substituted tricalcium phosphate (β-TCMP). Due to the presence of Mg in the calcite lattice, conversion to β-TCMP occurs preferentially to hydroxyapatite formation. The converted β-TCMP still maintains the three-dimensional interconnected porous structures of the original spine. The main conversion mechanism is the ion-exchange reaction, although there is also a dissolution–reprecipitation process that forms some calcium phosphate precipitates on the surfaces of the spine network. The average fracture strength of urchin spines and converted spines (β-TCMP) in the compression tests are 42 and 23 MPa, respectively. In vivo studies using a rat model demonstrated new bone growth up to and around the β-TCMP implants after implantation in rat femoral defects for 6 weeks. Some new bone was found to migrate through the spine structural pores, starting from the outside of the implant through the pores at the edge of the implants. These results indicate good bioactivity and osteoconductivity of the porous β-TCMP implants.

Keywords
Bioresorbable; Urchin spine; Calcium phosphate; Magnesium; Hydrothermal reaction
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Conversion of sea urchin spines to Mg-substituted tricalcium phosphate for bone implants
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 3, Issue 5, September 2007, Pages 785–793
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us