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Production of optically active 1,2,4-butanetriol from corresponding racemate by Microbial stereoinversion

Paper ID Volume ID Publish Year Pages File Format Full-Text
22231 43262 2007 3 PDF Available
Title
Production of optically active 1,2,4-butanetriol from corresponding racemate by Microbial stereoinversion
Abstract

Sterigmatomyces elviae DSM 70852 produced 12 g/l (S)-1,2,4-butanetriol (enantiomeric excess >99.9%) from 20 g/l racemate in 82 h. From the results of the inversion of an (R)-isomer to an (S)-isomer and GC-MS, it was suggested that (R)-1,2,4-butanetriol is oxidized to 1,4-dihydroxy-2-butanone, which is reduced to an (S)-isomer.

Keywords
(S)-1,2,4-butanetriol production; 1,2,4-butanetriol dehydrogenase; microbial stereoinversion; Sterigmatomyces elviae
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Production of optically active 1,2,4-butanetriol from corresponding racemate by Microbial stereoinversion
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 103, Issue 5, May 2007, Pages 494–496
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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