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Involvement of oxidative stress induction in Na+ toxicity and its relation to the inhibition of a Ca2+-dependent but calcineurin-independent mechanism in Saccharomyces cerevisiae

Paper ID Volume ID Publish Year Pages File Format Full-Text
22246 43263 2006 3 PDF Available
Title
Involvement of oxidative stress induction in Na+ toxicity and its relation to the inhibition of a Ca2+-dependent but calcineurin-independent mechanism in Saccharomyces cerevisiae
Abstract

Uridine 5′-hexadecylphosphate (UMPC16) inhibited the growth of Saccharomyces cerevisiae under a hypersaline stress condition with Na+ more strongly than the calcineurin inhibitor cyclosporine A (CsA). Additional Ca2+ supplementation similarly suppressed the inhibitory activities of UMPC16 and CsA on yeast cell growth in a medium with Na+. UMPC16, but not CsA, accelerated mitochondrial reactive oxygen species (ROS) generation in combination with Na+, suggesting its inhibition of a Ca2+-dependent but calcineurin-independent mechanism for protection against Na+ toxicity.

Keywords
Saccharomyces cerevisiae; salt stress; calcineurin
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Involvement of oxidative stress induction in Na+ toxicity and its relation to the inhibition of a Ca2+-dependent but calcineurin-independent mechanism in Saccharomyces cerevisiae
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 101, Issue 1, January 2006, Pages 77–79
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
You save - $31
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