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Anti-aging effect of rice wine in cultured human fibroblasts and keratinocytes

Paper ID Volume ID Publish Year Pages File Format Full-Text
22258 43264 2009 6 PDF Available
Title
Anti-aging effect of rice wine in cultured human fibroblasts and keratinocytes
Abstract

The application of rice wine on skin is known to have beneficial effects such as enhancement of the skin barrier function and skin whitening. In this study, we focused on examination of the anti-aging effects of rice wine. The treatment of fibroblasts with rice wine in vitro increased the expression of procollagen and laminin-5, a key basement membrane component in cultured human fibroblasts. Rice wine significantly reduced the expression of UV-induced matrix metalloproteinase-1 (MMP-1) in a dose-dependent manner in both cultured human fibroblasts and keratinocytes. In addition, treatment with rice wine decreased UV-induced tumor necrosis factor-α (TNF-α) production in human keratinocytes. An in vivo study using hairless mice showed that topical application of rice wine protected mouse skin from photoaging. Thus, we suggest that rice wine may have potential as an effective agent for the prevention and treatment of UV-induced skin aging.

Keywords
AP-1, activating protein-1; BM, basement membrane; CCL27, skin-associated chemokine; COX-2, cyclooxygenase; DEJ, dermal-epidermal junction; ECM, extracellular matrix; EGF, epidermal growth factor; ELISA, enzyme-linked immunosorbent assay; H&E, haematoxyli
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 107, Issue 3, March 2009, Pages 266–271
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us