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Neurite outgrowths of neurons with neurotrophin-coated carbon nanotubes

Paper ID Volume ID Publish Year Pages File Format Full-Text
22341 43270 2007 5 PDF Available
Title
Neurite outgrowths of neurons with neurotrophin-coated carbon nanotubes
Abstract

Multiwalled carbon nanotubes (CNTs) coated with neurotrophin were used to regulate the differentiation and survival of neurons. Neurotrophin (nerve growth factor [NGF] or brain-derived neurotrophic factor [BDNF]) was covalently bound to CNTs modified by amino groups using a 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) reagent. The CNTs coated with NGF or BDNF promoted the neurite outgrowths of neurons in the same manner as soluble NGF and soluble BDNF. By enzyme-linked immunosorbent assay (ELISA), we demonstrated that neurotrophin-coated CNTs carry neurotrophin. These results suggest that neurotrophin-coated CNTs have biological activity and stimulate the neurite outgrowths of neurons.

Keywords
brain-derived neurotrophic factor; nerve growth factor; neuron; neurite outgrowth; neurotrophin-coated carbon nanotubeBDNF, brain-derived neurotrophic factor; CNT, carbon nanotube; DRG, dorsal root ganglion; EDC, 1-ethyl-3-(3-dimethylaminopropyl) carbodii
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 103, Issue 3, March 2007, Pages 216–220
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us