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Electrochemical biosensor array for liver diagnosis using silanization technique on nanoporous silicon electrode

Paper ID Volume ID Publish Year Pages File Format Full-Text
22357 43271 2007 6 PDF Available
Title
Electrochemical biosensor array for liver diagnosis using silanization technique on nanoporous silicon electrode
Abstract

An electrochemical biosensor array system was fabricated for the diagnosis and monitoring of liver diseases. Analysis on this array system with multiple samples was performed for point-of-care testing or home-use applications. Cholesterol, bilirubin and aminotransferases present in the serum are well-known biomarkers for liver diseases. For this study, we describe our biosensor array system consisting of cholesterol, bilirubin and glutamate sensors. To immobilize sensing enzymes on the array system, we employed a silanization technique. We observed that porous silicon layers formed on each working electrode notably increase the effective surface area. Sensing electrodes were placed in sampling wells to minimize the cross-interference effect so that multiple sampling would be possible with a low noise current. Compared with traditional analyte measurement procedures, our novel analytical device demonstrated acceptable sensitivities for the analyses of multiple samples and analytes without a marked cross-interference effect. The device sensitivities observed were 0.2656 μA/mM for cholesterol, 0.15354 mA/mM for bilirubin, 0.13698 μA/(U/l) for alanine aminotransferase (ALT) and 0.45439 μA/(U/l) for aspartate aminotransferase (AST).

Keywords
cholesterol sensor; bilirubin sensor; glutamate sensor; alanine aminotransferase (ALT)/aspartate aminotransferase (AST) activities; biosensor array; porous silicon; electrochemical biosensor
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Electrochemical biosensor array for liver diagnosis using silanization technique on nanoporous silicon electrode
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 103, Issue 1, January 2007, Pages 32–37
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us