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Suppressive effect of poly-γ-glutamate on SOS response of Salmonella typhimurium induced by chemical mutagens

Paper ID Volume ID Publish Year Pages File Format Full-Text
22406 43274 2008 4 PDF Available
Title
Suppressive effect of poly-γ-glutamate on SOS response of Salmonella typhimurium induced by chemical mutagens
Abstract

We studied the suppressive effect of poly-γ-glutamate (PGA) on the SOS response of Salmonella typhimurium induced by several direct [furylframide, AF-2; N-methyl-N′-nitro-N-nitrosoguanidine, MNNG; and 4-nitroquinoline 1-oxide, 4NQO] and indirect [3-amino-1-methyl-5H-pyrido-(4,3-b) indole, Trp-P-2; 2-amino-3-methylimidazo (4,5-f) quinoline, IQ; and 2-amino-3,8-dimethylimidazo (4,5-f) quinoxaline, MeIQx] mutagens. PGA preparations with average molecular masses of 50, 2000, 4000, 6000, and 8000 kDa from Bacillus subtilis (chungkookjang) were used. When we used PGA Na salt with a molecular mass of 4000 kDa, the suppression rate increased with increasing PGA concentration; 3% PGA showed 80–90% suppression irrespective of the type of chemical mutagen. PGA preparations with molecular masses of 50 kDa and more than 6000 kDa were less effective. Glutamate and acidic polymers such as carboxymethylcellulose and xanthan gum showed lower suppressive effects than PGA. PGA proved to have high antimutagenic activity.

Keywords
poly-γ-glutamate; SOS response; Salmonella typhimurium; antimutagenic activity
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Suppressive effect of poly-γ-glutamate on SOS response of Salmonella typhimurium induced by chemical mutagens
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 105, Issue 6, June 2008, Pages 690–693
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us