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Combination of poly(ethylenimine) and chitosan induces high gene transfection efficiency and low cytotoxicity

Paper ID Volume ID Publish Year Pages File Format Full-Text
22451 43284 2008 4 PDF Available
Title
Combination of poly(ethylenimine) and chitosan induces high gene transfection efficiency and low cytotoxicity
Abstract

In this study, the cytotoxicity and transfection efficiency of using chitosan/DNA complex combined with poly(ethylenimine) (PEI) were investigated. The combination of PEI with the chitosan/DNA complex markedly enhanced the gene expression of HeLa cells to 1000-fold of that induced by chitosan alone. PEI’s cytotoxicity was considerably decreased upon combination with the chitosan/DNA complex. Furthermore, the PEI/chitosan/DNA could maintain the gene expression efficiency in the presence of serum.

Keywords
poly(ethylenimine); chitosan; cytotoxicity; transfection; serum
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Combination of poly(ethylenimine) and chitosan induces high gene transfection efficiency and low cytotoxicity
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 105, Issue 1, January 2008, Pages 65–68
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us