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Glucose-stimulated cAMP-protein kinase a pathway in yeast Saccharomyces cerevisiae

Paper ID Volume ID Publish Year Pages File Format Full-Text
22471 43291 2007 6 PDF Available
Title
Glucose-stimulated cAMP-protein kinase a pathway in yeast Saccharomyces cerevisiae
Abstract

In the yeast Saccharomyces cerevisiae, glucose signals activate the production of cellular cAMP. This signaling pathway is called the cAMP-protein kinase A (PKA) pathway, which plays a major role in the regulation of cell growth, metabolism, and stress resistance. Extensive studies have been carried out to clarify the mechanism of this pathway, and many factors involved in the pathway have been identified such as small G proteins, the GDP-GTP exchange factor, adenylate cyclase, and PKA. Also, additional elements involved in this pathway have been evaluated in the last decade. A heterotrimeric G protein α subunit was identified as a mammalian Gα homologue, and a G-protein-coupled receptor (GPCR), which initiates the signaling pathway in response to glucose addition, was identified. GPCR-Gα was shown to function in a signaling pathway that acts parallel to small G proteins. These signaling pathways regulate cell growth and differentiation in response to nutrients.

Keywords
glucose signal; G-protein-coupled receptor; cAMP; mitogen-activated protein kinase; pseudohyphal growth; cell size
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Glucose-stimulated cAMP-protein kinase a pathway in yeast Saccharomyces cerevisiae
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 104, Issue 4, October 2007, Pages 245–250
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
You save - $31
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