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Inhibitory effect of d-allose on neutrophil activation after rat renal ischemia/reperfusion

Paper ID Volume ID Publish Year Pages File Format Full-Text
22481 43291 2007 5 PDF Available
Title
Inhibitory effect of d-allose on neutrophil activation after rat renal ischemia/reperfusion
Abstract

d-Allose is one of the rare sugars produced from d-psicose. We examined whether d-allose reduces the extent of rat renal ischemia/reperfusion (I/R) injury by suppressing the activation of neutrophils. The renal concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and myeloperoxidase were significantly increased after renal I/R. These increases were significantly inhibited by d-allose administration. Furthermore, d-allose significantly inhibited the increase in the concentrations of blood urea nitrogen (BUN), creatinine, N-acetyl β-d-glucosaminidase (NAG) and histopathologic changes after renal I/R. These findings strongly suggest that d-allose protects against I/R-induced renal injury by inhibiting the activation of neutrophils that play an important role in I/R-induced renal injury. These findings may have important implications in understanding the biologic functions of d-allose. d-Allose may prove useful in renal surgery and transplantation.

Keywords
d-allose; neutrophil; renal ischemia; reperfusion injury; cytokine-induced neutrophil chemoattractant-1 (CINC-1)
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Inhibitory effect of d-allose on neutrophil activation after rat renal ischemia/reperfusion
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 104, Issue 4, October 2007, Pages 304–308
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us