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Recognition and effective degradation of 17β-estradiol by anti-estradiol-antibody-immobilized TiO2 nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
22487 43291 2007 4 PDF Available
Title
Recognition and effective degradation of 17β-estradiol by anti-estradiol-antibody-immobilized TiO2 nanoparticles
Abstract

Polyelectrolyte polyacrylic acid (PAA), used in the chemical modification of titanium dioxide (TiO2) nanoparticles, allows TiO2 nanoparticles to remain in suspension at neutral pH. The anti-17β-estradiol (E2) antibody was immobilized on PAA-modified TiO2 (PAA-TiO2) nanoparticles via covalent bonding between the carboxylic acid of PAA and the amino group of the antibody. The anti-E2-antibody-immobilized TiO2 (E2Ab-PAA-TiO2) nanoparticles can form a suspension at neutral pH, with a particle size of less than 100 nm. The E2-PAA-TiO2 nanoparticles caused the photocatalytic degradation of a typical TiO2 substrate, methylene blue. The anti-E2 antibody immobilized on the TiO2 surface recognized and bound E2 in the solution, thereby improving the efficiency of E2 degradation compared with that of PAA-TiO2 nanoparticles. These results demonstrate that the E2Ab-PAA-TiO2 nanoparticles developed in this study can be used in water treatment technology. Furthermore, this strategy of immobilizing proteins on nanoscale TiO2 particles creates new applications not only in the treatment of environmental waste, but also in medical and public sanitation processes.

Keywords
titanium dioxide; nanoparticle; 17β-estradiol; photocatalyst; polyacrylic acid
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Recognition and effective degradation of 17β-estradiol by anti-estradiol-antibody-immobilized TiO2 nanoparticles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 104, Issue 4, October 2007, Pages 339–342
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us