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Poly(dimethylsiloxane) elastomers with tethered peptide ligands for cell adhesion studies

Paper ID Volume ID Publish Year Pages File Format Full-Text
2250 107 2010 5 PDF Available
Title
Poly(dimethylsiloxane) elastomers with tethered peptide ligands for cell adhesion studies
Abstract

Poly(dimethylsiloxane) (PDMS) is the choice of material for a wide range of biological and non-biological applications because of its chemical inertness, non-toxicity, ease of handling and commercial availability. However, PDMS exhibits uncontrolled protein adsorption and cell adhesion and it has proved difficult to functionalize to present bioactive ligands. We present a facile strategy for functional surface modification of PDMS using commercial reagents to engineer polymer brushes of oligo(ethylene glycol) methacrylate that prevent cell adhesion and can be functionalized to display bioadhesive ligands. The polymer brushes resist biofouling and prevent cell adhesion and bioadhesive peptides can be tethered either uniformly or constrained to micropatterned domains using standard peptide chemistry approaches. This approach is relevant to various biomedical and biotechnological applications.

Keywords
Deformable substrate; Fibronectin; Cell mechanics; Focal adhesion
First Page Preview
Poly(dimethylsiloxane) elastomers with tethered peptide ligands for cell adhesion studies
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 8, August 2010, Pages 2898–2902
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering