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Novel in vitro screening system for monoclonal antibodies using hypermutating chicken B cell library

Paper ID Volume ID Publish Year Pages File Format Full-Text
22524 43300 2006 4 PDF Available
Title
Novel in vitro screening system for monoclonal antibodies using hypermutating chicken B cell library
Abstract

Here, we report an in vitro screening system for monoclonal antibodies using a hypermutating chicken B cell line, DT40-SW. When switching on hypermutation, cultured DT40-SW cells constituted an antibody library, from which clones secreting antibodies to a test antigen were successfully isolated, and genetically stabilized by switching off the mutation machinery.

Keywords
monoclonal antibody; chicken B cell line; hypermutation
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Novel in vitro screening system for monoclonal antibodies using hypermutating chicken B cell library
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Bioscience and Bioengineering - Volume 102, Issue 5, November 2006, Pages 478–481
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us