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The resorption of nanocrystalline calcium phosphates by osteoclast-like cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
2288 107 2010 11 PDF Available
Title
The resorption of nanocrystalline calcium phosphates by osteoclast-like cells
Abstract

Nanocrystalline calcium phosphates containing carbonate have a high similarity to bone mineral. The reactions of bone cells (primary osteoblasts and osteoclast-like cells) on these materials as well as on sintered β-tricalcium phosphate and hydroxyapatite (HA) confirmed a good biocompatibility of the nanocrystalline samples. However, osteoclastic differentiation was constrained on the carbonate-rich samples, leading to a small number of osteoclast-like cells on the materials and few resorption pits. The grain size of the calcium phosphate ceramics (nano vs. micro) was less important than expected from to physico-chemical considerations. When comparing the nanocrystalline samples, the highest resorption rate was found for nano-HA with a low carbonate content, which strongly stimulated the differentiation of osteoclast-like cells on its surface.

Keywords
Calcium phosphate; Bone substitution materials; Resorption; Osteoblasts; Osteoclast-like cells
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The resorption of nanocrystalline calcium phosphates by osteoclast-like cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 8, August 2010, Pages 3223–3233
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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