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Quorum quenching enzymes

Paper ID Volume ID Publish Year Pages File Format Full-Text
22949 43402 2015 13 PDF Available
Title
Quorum quenching enzymes
Abstract

•Enzymatic inactivation of quorum sensing signal molecules is wide-spread in nature.•Quorum quenching enzymes are potential anti-virulence tools.•Signal degrading bacteria may be used as biocontrol strains in agriculture.•Signal degrading bacteria may be applied as probiotics in aquaculture.•Quorum quenching enzymes or bacteria mitigate biofouling in membrane bioreactors.

Bacteria use cell-to-cell communication systems based on chemical signal molecules to coordinate their behavior within the population. These quorum sensing systems are potential targets for antivirulence therapies, because many bacterial pathogens control the expression of virulence factors via quorum sensing networks. Since biofilm maturation is also usually influenced by quorum sensing, quenching these systems may contribute to combat biofouling. One possibility to interfere with quorum sensing is signal inactivation by enzymatic degradation or modification. Such quorum quenching enzymes are wide-spread in the bacterial world and have also been found in eukaryotes. Lactonases and acylases that hydrolyze N-acyl homoserine lactone (AHL) signaling molecules have been investigated most intensively, however, different oxidoreductases active toward AHLs or 2-alkyl-4(1H)-quinolone signals as well as other signal-converting enzymes have been described. Several approaches have been assessed which aim at alleviating virulence, or biofilm formation, by reducing the signal concentration in the bacterial environment. These involve the application or stimulation of signal-degrading bacteria as biocontrol agents in the protection of crop plants against soft-rot disease, the use of signal-degrading bacteria as probiotics in aquaculture, and the immobilization or entrapment of quorum quenching enzymes or bacteria to control biofouling in membrane bioreactors. While most approaches to use quorum quenching as antivirulence strategy are still in the research phase, the growing number of organisms and enzymes known to interfere with quorum sensing opens up new perspectives for the development of innovative antibacterial strategies.

Keywords
AHL, N-acyl homoserine lactone; AI-2, autoinducer-2; AQ, 2-alkyl-4(1H)-quinolone; Cx-HSL, N-acyl homoserine lactone with x denominating the acyl chain length; DPD, 4,5-dihydroxy-2,3-pentanedione; DSF, diffusible signal factor; HDL, high-density lipoprotei
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Quorum quenching enzymes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 201, 10 May 2015, Pages 2–14
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us