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Prediction and optimization of the laccase-mediated synthesis of the antimicrobial compound iodine (I2)

Paper ID Volume ID Publish Year Pages File Format Full-Text
22981 43408 2015 3 PDF Available
Title
Prediction and optimization of the laccase-mediated synthesis of the antimicrobial compound iodine (I2)
Abstract

•Development of an ANN-GA hybrid model for laccase-mediated iodine (I2) synthesis.•The most important process parameters are identified and optimal regulated.•ANN-GA optimized parameters resulted in a 9.9% increase in conversion rate.

An artificial neural network (ANN) and genetic algorithm (GA) were applied to improve the laccase-mediated oxidation of iodide (I−) to elemental iodine (I2). Biosynthesis of iodine (I2) was studied with a 5-level-4-factor central composite design (CCD). The generated ANN network was mathematically evaluated by several statistical indices and revealed better results than a classical quadratic response surface (RS) model. Determination of the relative significance of model input parameters, ranking the process parameters in order of importance (pH > laccase > mediator > iodide), was performed by sensitivity analysis. ANN-GA methodology was used to optimize the input space of the neural network model to find optimal settings for the laccase-mediated synthesis of iodine. ANN-GA optimized parameters resulted in a 9.9% increase in the conversion rate.

Keywords
Artificial neural network; Bioprocess modeling; Design of experiments; Genetic algorithm; Response surface methodology
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Prediction and optimization of the laccase-mediated synthesis of the antimicrobial compound iodine (I2)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 193, 10 January 2015, Pages 134–136
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us