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Bioactivity improvement of poly(ε-caprolactone) membrane with the addition of nanofibrous bioactive glass

Paper ID Volume ID Publish Year Pages File Format Full-Text
2320 108 2008 8 PDF Available
Title
Bioactivity improvement of poly(ε-caprolactone) membrane with the addition of nanofibrous bioactive glass
Abstract

Nanofibrous glass with a bioactive composition was added to a degradable polymer poly(ε-caprolactone) (PCL) to produce a nanocomposite in thin membrane form (∼260 μm). The bioactivity and osteoblastic responses of the nanocomposite membrane were examined and compared with those of a pure PCL membrane. Glass nanofibers with diameters in the range of hundreds of nanometers were added to a PCL solution at 20 wt.%, and the mixture was stirred vigorously and air dried. The obtained nanocomposite membrane showed that many chopped glass nanofibers formed by the mixing step were embedded uniformly into the PCL matrix. The nanocomposite membrane induced the rapid formation of apatite-like minerals on the surface when immersed in a simulated body fluid. Murine-derived osteoblastic cells (MC3T3-E1) grew actively over the nanocomposite membrane with cell viability significantly improved compared with those on the pure PCL membrane. Moreover, the osteoblastic activity, as assessed by the expression of alkaline phosphatase, was significantly higher on the nanocomposite membrane than on the pure PCL membrane. The currently developed nanocomposite of the bioactive glass-added PCL might find applications in the bone regeneration areas such as the guided bone regeneration (GBR) membrane.

Keywords
Glass nanofiber; Poly(ε-caprolactone); Bioactivity; Osteoblast responses; Guided bone regeneration (GBR) model
First Page Preview
Bioactivity improvement of poly(ε-caprolactone) membrane with the addition of nanofibrous bioactive glass
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 3, May 2008, Pages 622–629
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering