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Current trends in polyhydroxyalkanoates (PHAs) biosynthesis: Insights from the recombinant Escherichia coli

Paper ID Volume ID Publish Year Pages File Format Full-Text
23217 43420 2014 14 PDF Available
Title
Current trends in polyhydroxyalkanoates (PHAs) biosynthesis: Insights from the recombinant Escherichia coli
Abstract

•The recent trends on PHAs production with wide ranges of diversities from E. coli has been summarized and covered.•Both conventional with new and novel PHAs has been included and provided with latest update.•Challenges of PHAs production has been discussed and novel insights from author are provided for further research.

Pursuing the current trend, the “green-polymers”, polyhydroxyalkanoates (PHAs) which are degradable and made from renewable sources have been a potential substitute for synthetic plastics. Due to the increasing concern towards escalating crude oil price, depleting petroleum resource and environmental damages done by plastics, PHAs have gained more and more attractions, both from industry and research. From the view point of Escherichia coli, a microorganism that used in the biopolymer large scale production, this paper describes the backgrounds of PHA and summarizes the current advances in PHA developments. In the short-chain-length (scl) PHAs section, the study of poly[(R)-3-hydroxybutyrate] [P(3HB)] as model polymer, ultra-high-molecular-weight P(3HB) which rarely discussed, and P(3HB-co-3HV), another commercialized PHA polymer are included. Other than that, this review also shed some light on the new members of PHA family, lactate-based PHAs and P(3HP) with topics such as block copolymers and invention of novel biopolymers. Flexibility of microorganisms in utilizing different carbon sources to accumulate medium-chain-length (mcl) PHAs and lastly, the promising scl-mcl-PHAs with interesting properties are also discussed.

Keywords
PHA, polyhydroxyalkanoates; MW, molecular weight; scl, short-chain-length; mcl, medium-chain-length; IPTG, isopropylthiogalactoside; Tg, glass transition temperature; Tm, melting temperature; Mr, relative molecular mass; DCW, dry cell weight; PDI, polydis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 180, 20 June 2014, Pages 52–65
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us