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Trypsin-catalyzed tandem reaction: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by in situ formed acetaldehyde

Paper ID Volume ID Publish Year Pages File Format Full-Text
23260 43426 2014 5 PDF Available
Title
Trypsin-catalyzed tandem reaction: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by in situ formed acetaldehyde
Abstract

•A simple, mild, one-pot tandem method catalyzed by trypsin was developed for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones.•Trypsin was found to display dual promiscuous functions to catalyze transesterification and the Biginelli reaction in sequence.•A Biginelli reaction using in situ-produced acetaldehyde was developed.•The 3,4-dihydropyrimidin-2(1H)-ones were synthesized through one-pot tandem reaction.•Trypsin displayed its dual promiscuous functions.

A simple, mild, one-pot tandem method catalyzed by trypsin was developed for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones by the Biginelli reaction of urea, β-dicarbonyl compounds, and in situ-formed acetaldehyde. Trypsin was found to display dual promiscuous functions to catalyze transesterification and the Biginelli reaction in sequence.

Keywords
Biginelli reaction; Tandem protocol; One-pot; Promiscuity; In situ
First Page Preview
Trypsin-catalyzed tandem reaction: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by in situ formed acetaldehyde
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 170, 20 January 2014, Pages 1–5
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering