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Enantiopure dihalocyclopropyl alcohols and esters by lipase catalyzed kinetic resolution

Paper ID Volume ID Publish Year Pages File Format Full-Text
23484 43441 2013 5 PDF Available
Title
Enantiopure dihalocyclopropyl alcohols and esters by lipase catalyzed kinetic resolution
Abstract

Four halogenated cyclopropane derivatives with a side chain containing a primary (1 and 2) or secondary (3 and 4) alcohol moiety were subject to kinetic resolution catalyzed by lipases. Two of them containing secondary alcohol groups gave excellent results with Candida antarctica lipase B with E-values around 1000. Two enantiopure alcohols and two enantiopure butanoates are described: (1S,1′S)-1-(2′,2′-dichloro-3′,3′-dimethylcyclopropyl) ethanol (3), the corresponding (1R,1′R)-butanoate (3b) and (1S,1′S)-1-(1′-methyl-2′,2′-dibromocyclopropyl) ethanol (4) and the corresponding (1R,1′R)-butanoate (4b).

Keywords
Enantiopure dihalocyclopropyl derivatives; Lipase catalysis; Kinetic resolution
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Enantiopure dihalocyclopropyl alcohols and esters by lipase catalyzed kinetic resolution
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 168, Issue 3, November 2013, Pages 284–288
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
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