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Scale-up of microbial processes: Impacts, tools and open questions

Paper ID Volume ID Publish Year Pages File Format Full-Text
23532 43449 2012 7 PDF Available
Title
Scale-up of microbial processes: Impacts, tools and open questions
Abstract

Industrial biotechnological production is developing rapidly worldwide. Consequently, more and novel bioprocesses need to perform optimally not only in small lab- but also in large production scales. This article shortly reviews typical impacts found when cells are exposed to micro environmental heterogeneities typically occurring in poorly mixed large scale production reactors. The current state-of-the-art of tool development is presented for analyzing these phenomena. Finally, still open questions are formulated and needs for future research are outlined to further support the expansion of biotech industries by successful research results.

► Current overview of the state-of-the art of scale-up impacts, approaches and tools is given. ► Scale-up insights are described based on own industrial expertise. ► To do's are formulated outlining the need to deduce biologically driven novel scale-up criteria.

Keywords
Scale-up; Bioprocesses
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 160, Issues 1–2, 31 July 2012, Pages 3–9
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us