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Controlled assembly of poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres under ultrasonic irradiation

Paper ID Volume ID Publish Year Pages File Format Full-Text
2360 109 2009 11 PDF Available
Title
Controlled assembly of poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres under ultrasonic irradiation
Abstract

An ultrasound field was applied to obtain PLGA/HAp biocomposite nanospheres. Formulation of PLGA/HAp composite revealed significant dependence of the morphology of the obtained composite on synthesis parameters, like the intensity of applied ultrasonic field, polymeric and ceramic parts’ wt.% ratio in the composite, temperature of the medium, type of surfactant, and the sequence of steps in the formation of PLGA/HAp. Optimal parameters for the formation of PLGA/HAp included a lower content of the ceramic phase (PLGA/HAp = 90:10), higher power of ultrasonic field (P = 142.4 W), lower temperature of the medium during ultrasonic treatment (T = 8 °C), dilute solution of PVP as surfactant and dispersion of hydroxyapatite in polymer solution in order to achieve required homogeneity before the formulation of the composite. The morphology of PLGA/HAp particles synthesized under these conditions was highly regular: sphere-like, with particles of very small dimensions (150–320 nm), highly uniform particle size distribution and characteristic planar spatial self-organization. These characteristics indicate significant improvements in PLGA/HAp composite resulting from ultrasonic method.

Keywords
Biocomposite; PLGA/hydroxyapatite; Nanospheres; Core–shell; Ultrasonic method
First Page Preview
Controlled assembly of poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres under ultrasonic irradiation
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 1, January 2009, Pages 208–218
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering