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The future of human DNA vaccines

Paper ID Volume ID Publish Year Pages File Format Full-Text
23621 43459 2012 12 PDF Available
Title
The future of human DNA vaccines
Abstract

DNA vaccines have evolved greatly over the last 20 years since their invention, but have yet to become a competitive alternative to conventional protein or carbohydrate based human vaccines. Whilst safety concerns were an initial barrier, the Achilles heel of DNA vaccines remains their poor immunogenicity when compared to protein vaccines. A wide variety of strategies have been developed to optimize DNA vaccine immunogenicity, including codon optimization, genetic adjuvants, electroporation and sophisticated prime-boost regimens, with each of these methods having its advantages and limitations. Whilst each of these methods has contributed to incremental improvements in DNA vaccine efficacy, more is still needed if human DNA vaccines are to succeed commercially. This review foresees a final breakthrough in human DNA vaccines will come from application of the latest cutting-edge technologies, including “epigenetics” and “omics” approaches, alongside traditional techniques to improve immunogenicity such as adjuvants and electroporation, thereby overcoming the current limitations of DNA vaccines in humans.

► Overview of strengths and weaknesses of previous DNA vaccine optimization strategies. ► Identifies new technologies (S/MAR vector, mcDNA, RNAi) relevant to DNA vaccine design. ► “Epigenetics” and “omics” technologies provide exciting new opportunities. ► Imminent breakthrough in human DNA vaccines incorporating latest technologies.

Keywords
DNA vaccine; Immunogenicity; Adjuvant; Epigenetics; RNAi; Omics
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The future of human DNA vaccines
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 162, Issues 2–3, 31 December 2012, Pages 171–182
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us