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Bioengineering of carbon fixation, biofuels, and biochemicals in cyanobacteria and plants

Paper ID Volume ID Publish Year Pages File Format Full-Text
23660 43460 2012 14 PDF Available
Title
Bioengineering of carbon fixation, biofuels, and biochemicals in cyanobacteria and plants
Abstract

Development of sustainable energy is a pivotal step towards solutions for today's global challenges, including mitigating the progression of climate change and reducing dependence on fossil fuels. Biofuels derived from agricultural crops have already been commercialized. However the impacts on environmental sustainability and food supply have raised ethical questions about the current practices. Cyanobacteria have attracted interest as an alternative means for sustainable energy productions. Being aquatic photoautotrophs they can be cultivated in non-arable lands and do not compete for land for food production. Their rich genetic resources offer means to engineer metabolic pathways for synthesis of valuable bio-based products. Currently the major obstacle in industrial-scale exploitation of cyanobacteria as the economically sustainable production hosts is low yields. Much effort has been made to improve the carbon fixation and manipulating the carbon allocation in cyanobacteria and their evolutionary photosynthetic relatives, algae and plants. This review aims at providing an overview of the recent progress in the bioengineering of carbon fixation and allocation in cyanobacteria; wherever relevant, the progress made in plants and algae is also discussed as an inspiration for future application in cyanobacteria.

► Carbon fixation is a major bottleneck in green biotechnology. ► We provide an in-depth summary of engineering of carbon fixation in cyanobacteria and plants. ► There is still room for improvements in carbon fixation through genetic engineering. ► Biochemical productions from metabolically engineered cyanobacteria are summarized.

Keywords
Cyanobacteria; Carbon fixation; Metabolic engineering; Biofuel; Synthetic pathways
First Page Preview
Bioengineering of carbon fixation, biofuels, and biochemicals in cyanobacteria and plants
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 162, Issue 1, 30 November 2012, Pages 134–147
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering