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Biocompatibility and bone mineralization potential of 45S5 Bioglass®-derived glass–ceramic scaffolds in chick embryos

Paper ID Volume ID Publish Year Pages File Format Full-Text
2377 109 2009 7 PDF Available
Title
Biocompatibility and bone mineralization potential of 45S5 Bioglass®-derived glass–ceramic scaffolds in chick embryos
Abstract

The aim of the present study was to evaluate the biocompatibility and bone mineralization potential of 45S5 Bioglass®-derived glass–ceramic scaffolds using a chick embryo shell-less (ex ovo) culture system. Chick embryos were divided into two groups: control (C) and experimental (E). Scaffolds were placed on the chorioallantoic membrane (CAM) in embryos of group E at 10 days of total incubation. The 45S5 Bioglass®-derived glass–ceramic scaffolds proved to be biocompatible in terms of the absence of inflammatory response at the implant site (CAM). Moreover, no alterations in the other end-points assessed, i.e. survival, stage of embryonic development and body weight, were detected. However, body length was greater in group E embryos than in group C embryos (p ⩽ 0.05). A marked reduction (93%) in Ca content in the scaffolds was evidenced by energy-dispersive X-ray analysis at 5 days post-implantation. Calcium release from the scaffold implanted on the CAM might have been responsible for the restoration of the bone-like phenotype in chick embryonic skeleton of group E as detected by Alcian blue–Alizarin red double staining, as well as by histological and microchemical analyses. Conversely, the control embryos exhibited a chondrogenic phenotype.

Keywords
Biocompatibility; Tissue engineering; Bioglass®; Scaffolds; Chick embryo
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Biocompatibility and bone mineralization potential of 45S5 Bioglass®-derived glass–ceramic scaffolds in chick embryos
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 1, January 2009, Pages 374–380
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us