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Mirror image phage display – Generating stable therapeutically and diagnostically active peptides with biotechnological means

Paper ID Volume ID Publish Year Pages File Format Full-Text
23793 43473 2012 5 PDF Available
Title
Mirror image phage display – Generating stable therapeutically and diagnostically active peptides with biotechnological means
Abstract

Peptides are attracting increasing attention as therapeutics. d-enantiomeric peptides are remarkably resistant to in vivo proteolysis and elicit low immunogenic responses when compared with the respective l-peptides. Therefore, d-peptides can serve as therapeutic and early diagnosis agents for drug development. Here we discuss the application of mirror image phage display in pharmaceutical biotechnology aiming to identify protease resistant d-peptides with biotechnological approaches.

► Peptides are attracting increasing attention as therapeutics. ► Phage display is used to identify peptides with desired properties out from huge libraries. ► Phage display yields peptides that consist of l-enantiomeric amino acid residues. ► l-peptides have disadvantageous properties as compared to d-peptides. ► Mirror image phage display uses all advantages of phage display and yields d-peptides.

Keywords
AD, Alzheimer's disease; Aβ, amyloid-β; Dag, hepatitis delta antigen; HDV, hepatitis delta virus; HIV-1, human immunodeficiency virus type 1; NMR, nuclear magnetic resonance; SH3, Src homology 3; ThT, thioflavineMirror image phage display; d-enantiomeric
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Mirror image phage display – Generating stable therapeutically and diagnostically active peptides with biotechnological means
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 161, Issue 2, 15 October 2012, Pages 121–125
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us