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Curcumin derivatives as new ligands of Aβ peptides

Paper ID Volume ID Publish Year Pages File Format Full-Text
23812 43474 2011 8 PDF Available
Title
Curcumin derivatives as new ligands of Aβ peptides
Abstract

Curcumin derivatives with high chemical stability, improved solubility and carrying a functionalized appendage for the linkage to other entities, have been synthesized in a straightforward manner. All compounds retained Curcumin ability to bind Aβ peptide oligomers without inducing their aggregation. Moreover all Curcumin derivatives were able to stain very efficiently Aβ deposits.

Keywords
Alzheimer's disease; Aβ peptides; Aβ ligands; Curcumin derivatives; NMR interaction studies; Conformational analysis; Brain amyloid plaque staining
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Curcumin derivatives as new ligands of Aβ peptides
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 156, Issue 4, 20 December 2011, Pages 317–324
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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