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In vitro and in vivo behaviour of zinc-doped phosphosilicate glasses

Paper ID Volume ID Publish Year Pages File Format Full-Text
2382 109 2009 10 PDF Available
Title
In vitro and in vivo behaviour of zinc-doped phosphosilicate glasses
Abstract

The aim of this work was to study the behaviour of zinc-doped phosphosilicate glasses based on Bioglass® 45S5. In vitro (in simulated body fluid), the reactivity was analysed by means of inductively coupled plasma spectrometry, environmental scanning electron microscopy–energy-dispersive spectroscopy (ESEM–EDS) and X-ray diffraction. In vivo (a rat implanted with glass), the reactivity and the tissue behaviour were analysed by conventional histology, histochemistry, microradiography and ESEM–EDS. The in vivo behaviour matches that in vitro perfectly; they show comparable glass degradation processes and rates, ruled by the amount of zinc in the glass. The reaction mechanism for the formation of a polymerized silica layer superimposed with a peripheral calcium phosphate layer is clearly substantiated by ESEM–EDS investigations. The crystallization of a biologically active hydroxyapatite (HA) layer is observed in both cases; the in vitro experiment shows the presence of HA after 4 days.

Keywords
Bioactive glasses; Zinc; In vitro test; In vivo test; Environmental scanning electron microscopy (ESEM)
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In vitro and in vivo behaviour of zinc-doped phosphosilicate glasses
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 1, January 2009, Pages 419–428
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us