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Repeated fed-batch fermentation using biosensor online control for citric acid production by Yarrowia lipolytica

Paper ID Volume ID Publish Year Pages File Format Full-Text
23829 43476 2011 5 PDF Available
Title
Repeated fed-batch fermentation using biosensor online control for citric acid production by Yarrowia lipolytica
Abstract

Biosensor-controlled substrate feeding was used in a citric acid production process with the yeast strain Yarrowia lipolytica H222 with glucose as the carbon source. The application of an online glucose biosensor measurement facilitated the performance of long-time repeated fed-batch process with automated bioprocess control. Ten cycles of repeated fed-batch fermentation were carried out in order to validate both the stability of the microorganism for citric acid production and the robustness of the glucose biosensor in a long-time experiment. In the course of this fermentation with a duration of 553 h, a slight loss of productivity from 1.4 g/(L × h) to 1.1 g/(L × h) and of selectivity for citric acid from 91% to 88% was observed. The glucose biosensor provided 6,227 measurements without any loss of activity.

Keywords
CA, citric acid; GL, glucose; ICA, isocitric acid; μmax, maximum specific growth rate; n.d., not determinate; PCA, volumetric productivity; pCA, biomass specific productivity of citric acid; SCA, selectivity of the bioprocess for the production of citric
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 153, Issues 3–4, 20 May 2011, Pages 133–137
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us