fulltext.study @t Gmail

Monte Carlo simulations of plasma membrane corral-induced EGFR clustering

Paper ID Volume ID Publish Year Pages File Format Full-Text
23885 43479 2011 10 PDF Available
Title
Monte Carlo simulations of plasma membrane corral-induced EGFR clustering
Abstract

Experimental evidence suggests that the cell membrane is a highly organized structure that is compartmentalized by the underlying membrane cytoskeleton (MSK). The interaction between the cell membrane and the cytoskeleton led to the “picket-fence” model, which was proposed to explain certain aspects of membrane compartmentalization. This model assumes that the MSK hinders and confines the motion of receptors and lipids to compartments in the membrane. However, the impact of the MSK on receptor clustering, aggregation, and downstream signaling remains unclear. For example, some evidence suggests that the MSK enhances dimerization, while other evidence suggests decreased dimerization and signaling. Herein, we use computational Monte Carlo simulations to examine the effects of MSK density and receptor concentration on receptor dimerization and clustering. Preliminary results suggest that the MSK may have the potential to induce receptor clustering, which is a function of both picket-fence density and receptor concentration.

Keywords
Plasma membrane; Membrane cytoskeleton; Picket fence; Clustering; Spatial modeling; EGFR
First Page Preview
Monte Carlo simulations of plasma membrane corral-induced EGFR clustering
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 151, Issue 3, 10 February 2011, Pages 261–270
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering