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Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
23982 43486 2010 7 PDF Available
Title
Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering
Abstract

In this study, computational fluid dynamics (CFD) analysis of a rotating-wall perfused-vessel (RWPV) bioreactor is performed to characterize the complex hydrodynamic environment for the simulation of cartilage development in RWPV bioreactor in the presence of tissue-engineered cartilage constructs, i.e., cell-chitosan scaffolds. Shear stress exerted on chitosan scaffolds in bioreactor was calculated for different rotational velocities in the range of 33–38 rpm. According to the calculations, the lateral and lower surfaces were exposed to 0.07926–0.11069 dyne/cm2 and 0.05974–0.08345 dyne/cm2, respectively, while upper surfaces of constructs were exposed to 0.09196–0.12847 dyne/cm2. Results validate adequate hydrodynamic environment for scaffolds in RWPV bioreactor for cartilage tissue development which concludes the suitability of operational conditions of RWPV bioreactor.

Keywords
Computational fluid dynamics; Rotating wall perfused vessel bioreactor; Cartilage; Tissue engineering
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Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 150, Issue 3, November 2010, Pages 389–395
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us