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Development and in vitro characterization of sol–gel derived CaO–P2O5–SiO2–ZnO bioglass

Paper ID Volume ID Publish Year Pages File Format Full-Text
2406 110 2007 8 PDF Available
Title
Development and in vitro characterization of sol–gel derived CaO–P2O5–SiO2–ZnO bioglass
Abstract

A CaO–P2O5–SiO2–ZnO bioglass was formed by the sol–gel technique and characterized by Raman spectroscopy, X-ray diffraction, energy dispersive X-ray analysis (EDXA) and scanning electron microscopy (SEM). The surface reactivity of the resultant glass-ceramic specimens was analyzed by immersion studies in simulated body fluid (SBF). SEM–EDXS and inductively coupled plasma atomic emission spectrometry techniques were used to monitor changes in the glass surface and SBF composition. Osteoblast cell culture experiments were performed to assess the biocompatibility and the alkaline phosphatase activity. Cell counts of the osteoblasts cultured on the bioglass samples were studied and compared with the polystyrene plates. The cells cultured on the bioglass disks consistently showed a higher alkaline phosphatase activity and cell counts compared to cells cultured on either polystyrene plates or the base CaO–P2O5–SiO2 bioglass. This was due to cell proliferation and differentiation promoted by the zinc-substituted bioglass.

Keywords
Sol–gel; Bioglass; SBF; Osteoblasts; Biocompatibility
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Development and in vitro characterization of sol–gel derived CaO–P2O5–SiO2–ZnO bioglass
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 3, Issue 2, March 2007, Pages 255–262
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us