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High-titer production of astaxanthin by the semi-industrial fermentation of Xanthophyllomyces dendrorhous

Paper ID Volume ID Publish Year Pages File Format Full-Text
24093 43496 2010 3 PDF Available
Title
High-titer production of astaxanthin by the semi-industrial fermentation of Xanthophyllomyces dendrorhous
Abstract

An improved semi-industrial process for astaxanthin production by fermentation of Xanthophyllomyces dendrorhous has been developed. The culture medium was designed at the flask scale, reaching an astaxanthin cellular content of 3.0 mg g−1 cell weight and a volumetric yield of 119 mg L−1 broth. Astaxanthin production in flask was significantly improved by white light (4.0 mg g−1 and 221 mg L−1), and by ultraviolet light (4.4 mg g−1 and 235 mg L−1). The scale-up to 10- and 800-L fermentors was developed by feeding with glucose. Representative data for illuminated fermentation processes are presented and discussed at the 10-L scale, where 420 mg L−1 (4.7 mg g−1) astaxanthin were produced, and the 800-L scale, with productivities of 350 mg L−1 (4.1 mg g−1) astaxanthin. The purity of the astaxanthin in the broth was about 84%, with accumulation of the following carotenoids other than astaxanthin: 4% β-carotene, 4% canthaxanthin, 5% HDCO, 1% zeaxanthin and 2% phoenicoxanthin. This technology can be easily scaled-up to an industrial application for the production of this xanthophyll widely demanded nowadays.

Keywords
Astaxanthin; Xanthophyll; Light; Industrial; Fermentation; Scale-up; Xanthophyllomyces dendrorhous
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 148, Issues 2–3, 20 July 2010, Pages 144–146
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us