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Structure monomorphism of RNA G-quadruplex that is independent of surrounding condition

Paper ID Volume ID Publish Year Pages File Format Full-Text
24183 43504 2010 5 PDF Available
Title
Structure monomorphism of RNA G-quadruplex that is independent of surrounding condition
Abstract

G-quadruplex structures in nucleic acids have become attractive targets of study because their distinct structural forms may have diverse biological functions. Here, we preliminary investigated the structure and thermodynamics of G-quadruplexes of RNAs and corresponding DNAs of the same sequence by CD, UV and PAGE. Structural analysis demonstrated that the RNA sequences folded into a parallel-stranded G-quadruplex independently of surrounding conditions with different cations (K+ and Na+) under both dilute and molecular crowding conditions. In contrast, G-quadruplexes of their corresponding DNA sequences showed structural polymorphism depending on the surrounding conditions. Moreover, it was demonstrated that parallel G-quadruplexes of the RNA sequences were more stable than either parallel or antiparallel G-quadruplexes of the same DNA sequences. These results allow us to propose a single, robust RNA G-quadruplex structure that exists under various conditions.

Keywords
RNA G-quadruplex; Molecular crowding conditions; Parallel/antiparallel G-quadruplexes; Thermodynamics
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Structure monomorphism of RNA G-quadruplex that is independent of surrounding condition
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 150, Issue 1, 1 October 2010, Pages 6–10
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us