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Promises, challenges and future directions of μCCAs

Paper ID Volume ID Publish Year Pages File Format Full-Text
24366 43509 2010 6 PDF Available
Title
Promises, challenges and future directions of μCCAs
Abstract

Micro-cell culture analogs (μCCAs) are a class of in vitro tissue analogs that combine multiple organ analogs on one microfluidic platform in physiologically correct volume ratios. The microfluidic platform also provides fluid flow rates and substance residence times close to those present in the human body. Several advantages arise from the microfluidic format that can be exploited for realistic simulations of drug absorption, metabolism and action. We envision that, together with theoretical modeling, μCCAs may produce reliable predictions of the efficacy of newly developed drugs. Advantages, challenges, and future directions of μCCAs are discussed and examples of systems are provided.

Keywords
Micro-cell culture analog; Microfluidics; Body on a chip; In vitro tissue
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 148, Issue 1, 1 July 2010, Pages 64–69
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us