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Development of liposome-based mimics of superoxide dismutase and peroxidase based on the “LIPOzyme” concept

Paper ID Volume ID Publish Year Pages File Format Full-Text
24401 43512 2010 5 PDF Available
Title
Development of liposome-based mimics of superoxide dismutase and peroxidase based on the “LIPOzyme” concept
Abstract

An antioxidative liposome catalyst, LIPOzyme, that mimics both superoxide dismutase (SOD) and peroxidase (POD)-like activities has been developed by using liposomes modified with simple ligands (dodecanoyl-histidine, Dodec-His) and metal ions (Mn). The SOD-like activity is dependent on the stability of the ligand–metal complex on the liposome membrane, with the value being higher for the DPPC liposome and at a higher pH. The POD-like activity was found to be maximal in the case of DMPC liposome, in which the ligand–metal complex is inserted more deeply into the membrane. It was thus shown that liposome modified with simple ligands can exhibit different enzyme-like activities depending on the characteristics of the liposome membrane.

Keywords
Membrane stress biotechnology; Liposome; LIPOzyme; Antioxidative enzymes; Enzyme mimics; Membranome
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Development of liposome-based mimics of superoxide dismutase and peroxidase based on the “LIPOzyme” concept
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 147, Issue 1, 3 May 2010, Pages 59–63
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us