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Mechanisms of yeast stress tolerance and its manipulation for efficient fuel ethanol production

Paper ID Volume ID Publish Year Pages File Format Full-Text
24465 43517 2009 8 PDF Available
Title
Mechanisms of yeast stress tolerance and its manipulation for efficient fuel ethanol production
Abstract

Yeast strains of Saccharomyces cerevisiae have been extensively studied in recent years for fuel ethanol production, in which yeast cells are exposed to various stresses such as high temperature, ethanol inhibition, and osmotic pressure from product and substrate sugars as well as the inhibitory substances released from the pretreatment of lignocellulosic biomass. An in-depth understanding of the mechanism of yeast stress tolerance contributes to breeding more robust strains for ethanol production, especially under very high gravity conditions. Taking advantage of the “omics” technology, the stress response and defense mechanism of yeast cells during ethanol fermentation were further explored, and the newly emerged tools such as genome shuffling and global transcription machinery engineering have been applied to breed stress resistant yeast strains for ethanol production. In this review, the latest development of stress tolerance mechanisms was focused, and improvement of yeast stress tolerance by both random and rational tools was presented.

Keywords
Saccharomyces cerevisiae; Stress tolerance; Ethanol fermentation
First Page Preview
Mechanisms of yeast stress tolerance and its manipulation for efficient fuel ethanol production
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 144, Issue 1, 12 October 2009, Pages 23–30
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering