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Light-curable polymer/calcium phosphate nanocomposite glue for bone defect treatment

Paper ID Volume ID Publish Year Pages File Format Full-Text
2449 112 2010 7 PDF Available
Title
Light-curable polymer/calcium phosphate nanocomposite glue for bone defect treatment
Abstract

Light-curable, methacrylate-based resins are clinically used for complex defect repair in dentistry (Heliobond®). The present study investigates how such easy-to-apply polymers may be used on a much broader range of applications, particularly for gluing wet bone. We investigate the significantly improved adhesion of the polymer to wet bone surfaces in a close to in vivo setup using freshly cut cow hip bone as a model. The use of a reactive filler (20 wt.% amorphous, glassy calcium phosphate nanoparticles, a-CaP) allows for combination of the properties of the polymer (strength; light-curing) and the reactive filler (recrystallization of amorphous CaP to hydroxyapatite within minutes). This filler alone has been earlier suggested for use as an injectable bone cement since it reacts under in vivo conditions within 10–15 min. Our study transfers this reactivity into a composite, thus using the reactive CaP phase to establish an improved adhesion of the composite to wet bone surfaces. Additional in vitro bioactivity tests, compressive and tensile strength suggest use of such light-curable nanocomposites for complex-shaped load-bearing implant materials and fracture repair.

Keywords
Amorphous calcium phosphate; Bis-GMA/TEGDMA; Biomineralization; Adhesion; Photopolymerization
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Light-curable polymer/calcium phosphate nanocomposite glue for bone defect treatment
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 7, July 2010, Pages 2704–2710
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us