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Optimisation of Dex-GMA nanoparticles prepared in modified micro-emulsion system: Physical and biologic characterization

Paper ID Volume ID Publish Year Pages File Format Full-Text
24523 43522 2009 6 PDF Available
Title
Optimisation of Dex-GMA nanoparticles prepared in modified micro-emulsion system: Physical and biologic characterization
Abstract

In recent years, utilizing nanoparticles as delivery system for drug targeting delivery has raised increasing interest. In this study, glycidyl methacrylate derivatized dextran (Dex-GMA) nanoparticles encapsulating basic fibroblast growth factor (bFGF) have been prepared inside the aqueous cores of sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/n-hexane reverse micelles. These nanoparticles were identified to be uniformly spherical in shape with an average size of 109.57 ± 2.09 nm. And 90.2% of the nanoparticles were in a narrow size range of 80–110 nm. The release of bFGF from the nanoparticles is completely and sustained as long as 35 days. The impact of the nanoparticles on mouse bone marrow mesenchymal stem cells (BMSCs) was assessed with cell cytotoxicity/viability and adhesion assay. Those studies show that the Dex-GMA nanoparticles prepared by water-in-oil micro-emulsion systems with aprotic solvent adding are novel, effective and biocompatible delivery system for bioactive protein.

Keywords
Drug delivery system; Nanoparticles; Reverse micelle; In vitro release
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 143, Issue 4, 25 September 2009, Pages 268–273
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us