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Substrate specificity of lipase from Burkholderia cepacia in the synthesis of 3′-arylaliphatic acid esters of floxuridine

Paper ID Volume ID Publish Year Pages File Format Full-Text
24549 43525 2009 4 PDF Available
Title
Substrate specificity of lipase from Burkholderia cepacia in the synthesis of 3′-arylaliphatic acid esters of floxuridine
Abstract

Among the five vinyl esters bearing phenyl ring in acyl moiety, the lipase from Burkholderia cepacia was most specific toward vinyl 4-phenylbutyrate. Additionally, 3′-regioselectivity of the enzyme was enhanced with the increment of acyl chain length. The lipophilic 3′-arylaliphatic acid esters of floxuridine, its potential prodrugs, were synthesized with high conversions (>98%) and good to excellent regioselectivities (85–99%) via the enzymatic approach.

Keywords
Lipase from Burkholderia cepacia; Chain-length specificity; Floxuridine; Nucleosides; Regioselective acylation; Enzyme catalysis
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Substrate specificity of lipase from Burkholderia cepacia in the synthesis of 3′-arylaliphatic acid esters of floxuridine
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 142, Issues 3–4, 15 July 2009, Pages 267–270
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us