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A game with many players: Control of gdh transcription in Corynebacterium glutamicum

Paper ID Volume ID Publish Year Pages File Format Full-Text
24582 43528 2009 9 PDF Available
Title
A game with many players: Control of gdh transcription in Corynebacterium glutamicum
Abstract

Glutamate dehydrogenase is a central enzyme connecting nitrogen and carbon metabolism via its precursors ammonium and oxoglutarate and its product glutamate. In Corynebacterium glutamicum glutamate dehydrogenase is especially important, since it is a key enzyme for the biotechnological production of the flavour enhancer l-glutamate. In this study, the regulation of gdh transcription was investigated. While originally described as a constitutively expressed gene, we could show that gdh transcription is highly variable depending on environmental conditions. Regulation of the gdh gene by the C. glutamicum nitrogen control protein AmtR was analyzed in detail in this study.

Keywords
Glutamate dehydrogenase; GlxR; Nitrogen control; Nitrogen regulation; Sigma factors; Stringent response
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A game with many players: Control of gdh transcription in Corynebacterium glutamicum
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 142, Issue 2, 15 June 2009, Pages 114–122
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us