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Bioinspired structure of bioceramics for bone regeneration in load-bearing sites

Paper ID Volume ID Publish Year Pages File Format Full-Text
2472 113 2007 9 PDF Available
Title
Bioinspired structure of bioceramics for bone regeneration in load-bearing sites
Abstract

The major problem with the use of porous bioceramics as bone regeneration grafts is their weak mechanical strength, which has not been overcome to date. Here we described a novel way to solve this problem. Beta-tricalcium phosphate (β-TCP) bioceramics with a bioinspired structure were designed and prepared with a porous cancellous core (porosity: 70–90%) inside and a dense compact shell (porosity: 5–10%) outside that mimics the characteristics of natural bone. They showed excellent mechanical properties, with a compressive strength of 10–80 MPa and an elastic modulus of 180 MPa–1.0 GPa, which could be tailored by the dense/porous cross-sectional area ratio obeying the rule of exponential growth. The in vitro degradation of the bioinspired bioceramics was faster than that of dense bioceramics but slower than that of porous counterparts. The changes in mechanical properties of the bioinspired ceramics during in vitro degradation were also investigated. A concept of the bioinspired macrostructure design of natural bone was proposed which provided a simple but effective way to increase the mechanical properties of porous bioceramics for load-bearing bone regeneration applications. It should be readily applicable to other porous materials.

Keywords
Bioinspired structure; Bioceramics; Calcium phosphate; Load-bearing sites; Bone regeneration
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Bioinspired structure of bioceramics for bone regeneration in load-bearing sites
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 3, Issue 6, November 2007, Pages 896–904
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us