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Micro- and nano-injectable composite biomaterials containing calcium phosphate coated with poly(dl-lactide-co-glycolide)

Paper ID Volume ID Publish Year Pages File Format Full-Text
2476 113 2007 9 PDF Available
Title
Micro- and nano-injectable composite biomaterials containing calcium phosphate coated with poly(dl-lactide-co-glycolide)
Abstract

Calcium phosphate/poly(dl-lactide-co-glycolide) (CP/DLPLG) composite biomaterial, in which each CP particle was coated with DLPLG, was synthesized. Two kinds of composites were prepared: microcomposite, with particles 150–200 μm in size, and nanocomposite, with the particles 40 ± 5 nm in size. Using nanoparticles, a new class of injectible composite biomaterials was produced. Based on scanning electron microscopy, atomic force microscopy, differential thermal analysis, thermogravimetric analysis, differential scanning calorimetry and Fourier transform infrared analyses, the structure and phase organization in both biomaterials was identified and in both studied cases CP particles were coated with DLPLG polymer. An injectable composite biomaterial, the characteristics of which depend on the ratio of the phases, was prepared by mixing physiological solution with the nano-CP/DLPLG composite. Rheological studies indicated a possible agglomeration of particles of the injectable nano-CP/DLPLG composite biomaterial with a CP content of 65%.

Keywords
Bone; Calcium phosphate; Composite; Copolymer; Nanocomposite
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Micro- and nano-injectable composite biomaterials containing calcium phosphate coated with poly(dl-lactide-co-glycolide)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 3, Issue 6, November 2007, Pages 927–935
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us