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Effect of biotic elicitors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures

Paper ID Volume ID Publish Year Pages File Format Full-Text
24760 43535 2009 5 PDF Available
Title
Effect of biotic elicitors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures
Abstract

The effect of biotic elicitors on the production of bilobalide and ginkgolides in Ginkgo biloba cell suspension cultures was studied. The treatment of cell cultures with Candida albicans and Staphylococcus aureus as elicitors increased the amounts of bilobalide (BB), ginkgolide A (GA) and ginkgolide B (GB), with slight growth inhibition. The native bacterial elicitor was more effective for secondary metabolite accumulations both in cells and culture medium than autoclaved. However, exposure times of the cells to the elicitors strongly influenced the production of BB, GA and GB. This study suggests that biotic elicitors can regulate the production of BB, GA and GB either directly or indirectly. These results also describe the establishment of optimum conditions that determine the effects of biotic elicitors on secondary metabolism of bilobalides.

Keywords
BB, bilobalide; GA, ginkgolide A; GB, ginkgolide B; KCTC, Korea Collection for Type CulturesGinkgo biloba; Bilobalide; Ginkgolide A; Ginkgolide B; Terpenoids; Cell suspension culture; Biotic elicitor
First Page Preview
Effect of biotic elicitors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 139, Issue 1, 1 January 2009, Pages 84–88
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering