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Multidimensional quantification of subcellular morphology of Saccharomyces cerevisiae using CalMorph, the high-throughput image-processing program

Paper ID Volume ID Publish Year Pages File Format Full-Text
24788 43537 2009 9 PDF Available
Title
Multidimensional quantification of subcellular morphology of Saccharomyces cerevisiae using CalMorph, the high-throughput image-processing program
Abstract

To quantitatively and multidimensionally assess the morphology of subcellular organelles and protein complexes in budding yeast cells, we applied our recently developed image-processing program, CalMorph. In this study, mitochondria, vacuole, endoplasmic reticulum, Golgi body, endosome, spindle pole body, and septin morphology were evaluated. In addition to the originally developed 501 parameters for cell wall morphology, nuclear DNA, and actin, we proposed an additional 610 parameters for the morphology of subcellular components, resulting in a total of 1111 quantitative parameters to evaluate the morphology of budding yeast. This approach enables one to conduct more detailed phenotypic studies, which is advantageous in yeast functional genomics.

Keywords
Cerevisiae; Organelle; CalMorph; Morphology; Image processing
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Multidimensional quantification of subcellular morphology of Saccharomyces cerevisiae using CalMorph, the high-throughput image-processing program
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 141, Issues 3–4, 20 May 2009, Pages 109–117
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us