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Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: A longitudinal study in a segmental bone defect model of rabbit

Paper ID Volume ID Publish Year Pages File Format Full-Text
2483 113 2007 12 PDF Available
Title
Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: A longitudinal study in a segmental bone defect model of rabbit
Abstract

Porous interconnected hydroxyapatite (HA) and HA/tricalcium phosphate (TCP) (60/40) ceramics are promising materials for hard tissue repair. However, the mechanical properties of these materials have not been accurately determined under weight-bearing conditions. In this study, newly developed HA and HA/TCP (60/40) ceramics were used with intramedullary fixation in segmental bone defects of rabbits. Early radiological, histological, densitometric and biomechanical changes were evaluated. The mean radiological grade of healing and bonding to bone was higher in HA/TCP (60/40) ceramics than that of pure HA ceramics but the difference was not statistically significant. The densities of both implanted ceramics improved with time, supported by the histological evaluation of bone matrix ingrowth into ceramic pores, whereas the densities at the bone–ceramic interface decreased gradually. Flexural resonant frequencies and three-point bending strength increased, revealing an increase in mechanical stability during this early critical time interval where implant and/or bone–implant interface failures occur frequently. It can be concluded that both HA and HA/TCP (60/40) ceramics have a limited application in the treatment of load-bearing segmental bone defects but did not fail at the early stages of implantation.

Keywords
Hydroxyapatite; Calcium phosphate ceramic; Early weight bearing; Bone defect; Biomechanics
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Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: A longitudinal study in a segmental bone defect model of rabbit
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 3, Issue 6, November 2007, Pages 985–996
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us