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Plant cell-based processes for cyclotides production

Paper ID Volume ID Publish Year Pages File Format Full-Text
24881 43542 2008 4 PDF Available
Title
Plant cell-based processes for cyclotides production
Abstract

Cyclotides are naturally occurring mini-proteins that have a diverse range of therapeutically useful biological activities. Although a choice of approaches is available for cyclotides synthesis; most studies have involved the use of peptides extracted from plants. In order to facilitate the screening for structure-activity studies or to exploit them in drug development, a convenient and reliable route for the biosynthesis of cyclotides is of vital importance.Callus, suspension cultures and hydroponic plants of Oldenlandia affinis were established and have been evaluated for effective cyclotides production processes. The specific accumulation of kalata B1 was affected by cell differentiation as well as agitation; highest accumulation of 2.7 mg g−1 dry weight was detected in agitated hydroponic plant cultures resulting in a productivity of 1.4 mg kalata B1 l−1 day−1.

Keywords
Oldenlandia affinis; In vitro cultures; Cyclotides; Kalata B1 production; Morphogenesis; Drug discovery
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Plant cell-based processes for cyclotides production
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 135, Issue 1, 20 May 2008, Pages 123–126
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us