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Bioreactor design for cornea tissue engineering: Material–cell interactions

Paper ID Volume ID Publish Year Pages File Format Full-Text
2489 113 2007 9 PDF Available
Title
Bioreactor design for cornea tissue engineering: Material–cell interactions
Abstract

Several materials were evaluated for potential use in a bioreactor system for a tissue-engineered cornea. Two types of cytotoxicity tests were performed using human corneal stromal fibroblasts: a 24 h cytotoxicity test based on the ASTM standard F813-01 and a 7 days growth inhibition test. It was determined that culture configuration, autoclaving and materials surface preparation were all important factors influencing cell viability. Poly(etheretherketone) and titanium–6Al–4V were found to be the most appropriate materials for use in a corneal bioreactor system. Furthermore, poly(oxymethylene) copolymer and poly(tetrafluoroethlylene) are not safe for use with human corneal fibroblasts after autoclaving.

Keywords
Corneal stromal fibroblasts; Polyoxymethylene homopolymer; Polyoxymethylene copolymer; Polyetheretherketone; UHMWPE
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Bioreactor design for cornea tissue engineering: Material–cell interactions
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 3, Issue 6, November 2007, Pages 1041–1049
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us