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Role of host protein Ebp1 in influenza virus growth: Intracellular localization of Ebp1 in virus-infected and uninfected cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
24927 43546 2008 5 PDF Available
Title
Role of host protein Ebp1 in influenza virus growth: Intracellular localization of Ebp1 in virus-infected and uninfected cells
Abstract

The cellular protein Ebp1 was identified to interact with PB1 protein of influenza virus RNA polymerase, and inhibit both RNA synthesis in vitro and influenza virus replication in vivo [Honda, A., Okamoto, T., Ishihama, A., 2007. Host factor Ebp1: selective inhibitor of influenza virus transcriptase. Genes Cells 12, 133–142]. The intracellular localization of Ebp1 that is involved in cell proliferation control was analyzed by direct immunostaining of cells before and after influenza virus infection. Ebp1 was found to localize in the nuclear membrane of uninfected cells, and to form nuclear aggregates with viral P proteins in virus-infected cells.

Keywords
Ebp1, ErbB3-binding protein 1; RdRp, RNA-dependent RNA polymerase; P proteins, PB1, PB2 and PA; SDS, sodium dodecyl sulfate; PAGE, polyacrylamide gel electrophoresis; ErbB3, epidermal receptor tyrosine kinase; HDAC2, histone deacetylase 2; Rb, retinoblast
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Role of host protein Ebp1 in influenza virus growth: Intracellular localization of Ebp1 in virus-infected and uninfected cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 133, Issue 2, 20 January 2008, Pages 208–212
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
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